Christina Applegate received shocking news from her doctor: she does not have multiple sclerosis. The actress had previously spoken openly about her struggle with MS and its effect on her life. Her 2021 diagnosis had since become central to her public story. The doctor’s conclusion means that MS can no longer account for the symptoms she has described. Applegate says she still does not know what is causing her ill health. She therefore remains without a confirmed diagnosis while seeking an explanation for what is happening to her body.